Milk intake at midlife and cognitive decline over 20 years. Association of lung function with cognitive decline and. Coronary artery calcification cac is an emerging marker for atherosclerosis, and past studies suggest that it predicts incident chd in asymptomatic populations. Virani, zhengzheng teng, eric boerwinkle, christie m. Epigenomewide association study ewas of bmi, bmi change. Moderate alcohol consumption has been found to be associated with lower risk of coronary heart disease and myocardial infarction, which share similar risk factors and pathophysiology with chronic kidney disease ckd. The atherosclerosis risk in communities aric study is an ongoing, prospective cohort study which was created to evaluate risk factors, progression, and outcomes of atherosclerosis in 15,792 participants 45% male, 74% white enrolled in the united states in 19871989.
Outcomes of atrial fibrillation ablation in morbidly obese patients following bariatric surgery compared with a nonobese cohort. Gain greater insights using contextual tools to visualize and analyze your data. Recently, af risk factors were identified in pooled analysis of 3 large cohorts fhs, aric and the cardiovascular health study chs and were externally validated in the age, gene and environmentreykjavik study ages and the rotterdam study rs. Aric krogstad1, yong gao2, kendall krebs2, eric arts2, meredith hunter1, celia labranche3, david monte. However, many did not adjust for important confounders or did not include women and non. Usual choline and betaine dietary intake and incident coronary heart disease. Mondul, phd, msph, of the university of michigan in ann arbor, and her colleagues prospectively examined 6,518 black and white men without prostate cancer at baseline in the aric atherosclerosis risk in communities study. Pdf cigarette smoking is a powerful risk factor for incident heart disease and stroke, but the. In 2005, the atherosclerosis risk in communities aric study began. Methods we followed 5807 men and 7252 women in the united states, 4564 yr old, initially free of cvd and cancer from 1987 through 2012, and used a life table approach to estimate lifetime risks of cvd coronary heart disease, heart failure, and stroke and total cancer according to pa levels. Folsom2 abstract there is a known inverse association between type 2 diabetes t2d and prostate cancer prca that is.
Atherosclerosis risk in communities aric study, improved casefatality. Maximum wall thickness and luminal area were measured with gadoliniumenhanced magnetic resonance mr imaging in both common carotid arteries ccas and in one internal carotid artery. Atherosclerosis risk in communities study aric biolincc. The aric study and cardiovascular health study chs were two large population based cohort studies that assessed the association of imt with coronary artery disease. Physical activity and lifetime risk of cardiovascular diseas.
Aric study included 12,841 men and women aged 4564 years, and followed them up for 47 years. Serum magnesium and risk of sudden cardiac death in the. Apol1 risk alleles, cardiac markers, and risk of eskd in. The atherosclerosis risk in communities aric study is a communitybased cohort study of 15 792 people aged 4564 years at baseline, sampled from four us communities. We studied participants from the aric study, which was designed to investigate the natural history and etiology of atherosclerosis and its sequelae.
Dietary protein restriction is recommended for patients with moderate to severe renal insufficiency. Both high and low percentages of carbohydrate diets were associated with increased mortality, with minimal risk observed at 5055% carbohydrate intake. The final questionnaire contained a total of 66 items. African americans face a high risk of chronic kidney disease and kidney failure compared with people of european ancestry. Aric is designed to investigate the etiology and natural history of atherosclerosis, the etiology of clinical atherosclerotic diseases, and variation in cardiovascular risk factors, medical care and disease by race, sex, place and time. Americans enrolled in the atherosclerosis risk in communities study.
Infiltrated atrial fat characterizes underlying atrial. We studied 10 975 men and women aged 4770 years 23% african. The aric study protocol and design have been previously described. Nutrients free fulltext a diet pattern with more dairy. This study aimed to assess the association between dietary protein sources and incident chronic kidney disease ckd. The complexity of the aric study requires that a sizeable number of procedures be described, thus this rather extensive list of materials has been organized into the set of manuals listed below. A probability sample of 15,792 residents 4564 years. The atherosclerosis risk in communities aric study. The presence of two risk alleles in the apol1 gene, a genotype present in % of african americans, is associated with a 2fold increased risk of endstage kidney disease eskd 1.
Kidney function is often compromised in frailty and is a key consideration in medication choice and dosing. The purpose of this study was to determine the association of cigarette smoking with incident af in a populationbased cohort of blacks and whites. Results from the atherosclerosis risk in communities aric study previous article associations among the chads2 score, atrial substrate properties, and outcome of catheter ablation in patients with paroxysmal atrial fibrillation. Importance of the heart vector origin point definition for an. Periodontitis has been linked to coronary heart disease chd risk, possibly through providing a systemic inflammatory burden. The atherosclerosis risk in communities study assessed risk factors and levels of serum mg in a cohort of 45 to 64yearold subjects in 19871989 n 14,232. Reflections are the building blocks of research papers and offer original points of view on the issues and concerns related to. Association of head injury with brain amyloid deposition. Longterm data on the relationship between dietary protein sources and risk for incident kidney disease in individuals with normal kidney function are largely missing. Atherosclerosis risk in communities aric cohort forms. The aric study is carried out as a collaborative study supported by national heart, lung, and blood institute contracts hhsn26820105c, hhsn26820106c, hhsn26820107c, hhsn26820108c, hhsn26820109c, hhsn26820110c, hhsn26820111c, and hhsn26820112c. We genotyped 2212 atherosclerosis risk in communities study participants 1,023.
Association between endogenous testosterone and cerebrovascular disease in the aric study atherosclerosis risk in communities. Milk is the primary source of lactose in the human diet, and its effects on cognitive decline have not been fully evaluated. Diabetes in midlife and cognitive change over 20 years. The aric study is carried out as a collaborative study supported by national heart, lung, and blood institute nhlbi contracts hhsn26820105c, hhsn26820106c, hhsn26820107c, hhsn26820108c, hhsn26820109c, hhsn26820110c, hhsn26820111c, and. Dietary protein sources and risk for incident chronic kidney. The atherosclerosis risk in communities study aric, sponsored by the national heart. Frail individuals are at increased risk for poor outcomes, including adverse drug events. Aric is a collaborative study supported by contracts. Details of the design, objectives, and quality control activities of the aric study have been previously reported aric investigators 1989. Atherosclerosis risk in communities aric study participants n 1980 underwent brain mr imaging from 2011 to 20 at four aric sites. Separating acute from chronic hf in populationbased studies would. The atherosclerosis risk in communities aric study is conducted and supported by the national heart, lung, and blood institute nhlbi in collaboration with the aric study investigators.
Methods we determined the risk of incident af through december 2002 in relation to baseline 19871989 smoking status and cigaretteyears of smoking in over 15,000 participants of the prospective. Associations of fish intake and dietary n3 polyunsaturated. Low carbohydrate dietary patterns favouring animalderived protein and fat sources, from sources such as lamb, beef, pork, and chicken, were associated with higher mortality, whereas those that favoured plantderived protein and fat intake. Atherosclerosis risk in communities aric study national heart. Epigenomewide association study ewas of bmi, bmi change, and waist circumference in african american adults identifies multiple replicated loci. Manuals 2 and 3 describe the operation of the cohort and. The authors thank the staff and participants of the aric study for their important contributions staff members are listed in appendix 2. Arcgis offers unique capabilities and flexible licensing for applying locationbased analytics to your business practices. Longterm, prospective epidemiologic studies have consistently shown that persons with healthier lifestyles and fewer risk factors for coronary heart disease, and particularly those with favorable lipid profiles, have reduced incidence of coronary heart disease. Few studies have evaluated periodontitis and subclinical measures of atherosclerosis. In the aric study it was shown that generalized retinal arteriolar narrowing is associated with incident clinical stroke. Mr imaging measures of intracranial atherosclerosis in a. Usual choline and betaine dietary intake and incident. The atherosclerosis risk in communities aric study by luchen weng 1, lyn m.
Atherosclerosis risk in communities study protocol manual. Previous studies reported a higher risk of cognitive decline and dementia amongst individuals with impaired lung function. Imaging included threedimensional blackblood mr imaging and timeofflight mr angiography. The association between parity and subsequent cardiovascular.
Participants included in this analysis were free of chronic cough and phlegm, wheezing, asthma, chronic bronchitis, emphysema, and other chronic lung conditions at the baseline examination, when they were aged 4564. Venous thromboembolism vte, presenting as deep venous thrombosis dvt andor pulmonary embolism pe, is a major public health problem 14 with a multifactorial etiology. Pdf cigarette smoking and progression of atherosclerosis. Television viewing, an indicator of sedentary behavior, was.
Here we describe the ascertainment methodology of the aric neurocognitive study. At visit 1 19871989, medication usage in the 2 weeks preceding the examination was determined by having participants bring their medications to. Find, read and cite all the research you need on researchgate. A diet pattern with more dairy and nuts, but less meat is related to lower risk of developing hypertension in middleaged adults. We used multiple linear and logistic models to regress lesion risk and intimamedia thickness on workrelated stress scores from a questionnaire administered at an 18month followup examination. In an ageadjusted model, the prevalence of carotid lesions among men scoring in the highest stress quintile was 36% compared. Dietary protein sources and risk for incident chronic. We choose aric af risk score over fhs af risk score because our study population is 1 bi.
The atherosclerosis risk in communities study aric is a prospective epidemiologic study being conducted in four u. Faster rates of cognitive decline are likely to result in earlier onset of cognitive impairment and dementia. Physical activity and lifetime risk of cardiovascular. Remodeling of carotid arteries detected with mr imaging. Classification of heart failure in the atherosclerosis risk in. Cyclooxygenase polymorphisms and risk of cardiovascular. A total of 2066 participants age range, 6085 years from the atherosclerosis risk in communities aric study were enrolled in the aric carotid mri study. Beginning with the second aric study visit, cognition was also assessed. Atherosclerosis risk in communities study collaborative studies.
The association of longterm exposure to particulate. Manual 1 provides the background, organization, and general objectives of the aric study. Research article diabetes genes and prostate cancer in the atherosclerosis risk in communities study tamra e. Atherosclerosis risk in communities study description. Prospective analysis of traffic exposure as a risk factor. We analyzed data from 8,967 participants from the atherosclerosis risk in communities aric study, a longitudinal cohort study. Part of this risk has been attributed to genetic factors. Dyslipidemia is an important risk factor for coronary artery disease and stroke. Importance of the heart vector origin point definition for.
The association of longterm exposure to particulate matter. Aric study design atherosclerosis risk in communities. Impact of aging on the development of hepatocellular. Steffen 1, moyses szklo 2, jennifer nettleton 3, lloyd chambless 4. The authors thank the staff and participants of the aric study for their important contributions. The aric study used retrospective community surveillance to monitor admis. Collaborate and share via maps, apps, dashboards and reports. Furthermore, existing studies used various methods of physical activity. Rawlings had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. The aric study is a communitybased prospective cohort study with 15,792 participants aged 45 to 64 years and enrolled in 1987 to 1989 visit 1 from 4 us communities forsyth county, nc. The authors conducted a study of a cohort of 469 patients with chronic hepatitis c virus and confirmed that alcohol consumption, the duration between infection and study entry, fibrosis, and patient. Depressive symptoms and the risk of type 2 diabetes.
923 414 1226 312 587 170 1217 892 1390 314 363 476 1297 27 212 356 658 350 1500 383 212 307 1139 912 1300 692 1168 1489 1022 782 1469 454 866 1133 1075 405 764 1275 461 685 105 1109 638 524